Allogeneic bone marrow supports human islet beta cell survival and function over six months.
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ABSTRACT:
SUBMITTER: Luo L
PROVIDER: S-EPMC3599775 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
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Allogeneic bone marrow supports human islet beta cell survival and function over six months.
Luo LuGuang L Badiavas Evangelos E Luo John Zq JZ Maizel Abby A
Biochemical and biophysical research communications 20070730 4
In this study, we have established a new strategy increasing human islet longevity utilizing allogeneic whole bone marrow (BM) co-cultured with human islets. The cultured islets' function and survival have been evaluated by analysis of insulin secretion in response to high-glucose-challenge, morphological evaluation of cell growth. Human islet only culture failed to reveal evidence of long term survival, growth or function in terms of insulin release or insulin response to glucose challenge. The ...[more]
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