Ontology highlight
ABSTRACT:
SUBMITTER: Kohl KP
PROVIDER: S-EPMC3599781 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Kohl Kathryn P KP Jones Corbin D CD Sekelsky Jeff J
Science (New York, N.Y.) 20121201 6112
Generation of meiotic crossovers in many eukaryotes requires the elimination of anti-crossover activities by using the Msh4-Msh5 heterodimer to block helicases. Msh4 and Msh5 have been lost from the flies Drosophila and Glossina, but we identified a complex of minichromosome maintenance (MCM) proteins that functionally replace Msh4-Msh5. We found that REC, an ortholog of MCM8 that evolved under strong positive selection in flies, interacts with MEI-217 and MEI-218, which arose from a previously ...[more]