Ontology highlight
ABSTRACT:
SUBMITTER: Park SR
PROVIDER: S-EPMC3600582 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Park Sook Ryun SR Chen Alice A
Hematology/oncology clinics of North America 20120601 3
Recently, the development of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors as a synthetic lethality approach has brought a major breakthrough in the treatment of breast cancer susceptibility gene (BRCA)-mutant cancers. Because sporadic cancers have also been found to commonly have other defects in DNA repair, PARP inhibitors are under active clinical investigation in combination with DNA-damaging therapeutics in a wide range of sporadic cancers. In this review, the authors disc ...[more]