Ontology highlight
ABSTRACT:
SUBMITTER: Karlsson KE
PROVIDER: S-EPMC3600728 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20130116
Drug development struggles with high costs and time consuming processes. Hence, a need for new strategies has been accentuated by many stakeholders in drug development. This study proposes the use of pharmacometric models to rationalize drug development. Two simulated examples, within the therapeutic areas of acute stroke and type 2 diabetes, are utilized to compare a pharmacometric model-based analysis to a t-test with respect to study power of proof-of-concept (POC) trials. In all investigated ...[more]