Ontology highlight
ABSTRACT:
SUBMITTER: Hendriks BS
PROVIDER: S-EPMC3600732 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Hendriks B S BS Reynolds J G JG Klinz S G SG Geretti E E Lee H H Leonard S C SC Gaddy D F DF Espelin C W CW Nielsen U B UB Wickham T J TJ
CPT: pharmacometrics & systems pharmacology 20121121
Nanoparticle encapsulation has been used as a means to manipulate the pharmacokinetic (PK) and safety profile of drugs in oncology. Using pegylated liposomal doxorubicin (PLD) vs. conventional doxorubicin as a model system, we developed and experimentally validated a multiscale computational model of liposomal drug delivery. We demonstrated that, for varying tumor transport properties, there is a regimen where liposomal and conventional doxorubicin deliver identical amounts of doxorubicin to tum ...[more]