Ontology highlight
ABSTRACT:
SUBMITTER: Stappert L
PROVIDER: S-EPMC3601127 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Stappert Laura L Borghese Lodovica L Roese-Koerner Beate B Weinhold Sandra S Koch Philipp P Terstegge Stefanie S Uhrberg Markus M Wernet Peter P Brüstle Oliver O
PloS one 20130318 3
MicroRNAs are key regulators of neural cell proliferation, differentiation and fate choice. Due to the limited access to human primary neural tissue, the role of microRNAs in human neuronal differentiation remains largely unknown. Here, we use a population of long-term self-renewing neuroepithelial-like stem cells (lt-NES cells) derived from human embryonic stem cells to study the expression and function of microRNAs at early stages of human neural stem cell differentiation and neuronal lineage ...[more]