Ontology highlight
ABSTRACT:
SUBMITTER: Gamazon ER
PROVIDER: S-EPMC3601550 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Gamazon E R ER Badner J A JA Cheng L L Zhang C C Zhang D D Cox N J NJ Gershon E S ES Kelsoe J R JR Greenwood T A TA Nievergelt C M CM Chen C C McKinney R R Shilling P D PD Schork N J NJ Smith E N EN Bloss C S CS Nurnberger J I JI Edenberg H J HJ Foroud T T Koller D L DL Scheftner W A WA Coryell W W Rice J J Lawson W B WB Nwulia E A EA Hipolito M M Byerley W W McMahon F J FJ Schulze T G TG Berrettini W H WH Potash J B JB Zandi P P PP Mahon P B PB McInnis M G MG Zöllner S S Zhang P P Craig D W DW Szelinger S S Barrett T B TB Liu C C
Molecular psychiatry 20120103 3
We conducted a systematic study of top susceptibility variants from a genome-wide association (GWA) study of bipolar disorder to gain insight into the functional consequences of genetic variation influencing disease risk. We report here the results of experiments to explore the effects of these susceptibility variants on DNA methylation and mRNA expression in human cerebellum samples. Among the top susceptibility variants, we identified an enrichment of cis regulatory loci on mRNA expression (eQ ...[more]