Ontology highlight
ABSTRACT:
SUBMITTER: Kim SJ
PROVIDER: S-EPMC3601786 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Kim Seong Jong SJ Lin Chun Chieh CC Pan Chung-Mao CM Rananaware Dimple P DP Ramsey Deborah M DM McAlpine Shelli R SR
MedChemComm 20121129 2
We report the synthesis, cytotoxicity, and phenotypic analysis of oxazole and thiazole containing fragments. Evaluating the optimal size and heterocycle for growth inhibition and apoptosis showed that activity required at least two thiazoles sequentially connected. This is the first detailed comparison of biological activity between multi-heterocyclic containing fragments. ...[more]