Dataset Information

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.

ABSTRACT: A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI tract was observed. Thus, a new, orally administered CA for MRI of the GI tract has been developed and successfully demonstrated.

SUBMITTER: Martinez GV

PROVIDER: S-EPMC3602218 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature

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Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.

Martinez Gary V GV Navath Suryakiran S Sewda Kamini K Rao Venkataramanarao V Foroutan Parastou P Alleti Ramesh R Moberg Valerie E VE Ahad Ali M AM Coppola Domenico D Lloyd Mark C MC Gillies Robert J RJ Morse David L DL Mash Eugene A EA

Bioorganic & medicinal chemistry letters 20130213 7

A scaffold bearing eight terminal alkyne groups was synthesized from sucrose, and copies of an azide-terminated Gd-DOTA complex were attached via copper(I)-catalyzed azide-alkyne cycloaddition. The resulting contrast agent (CA) was administered by gavage to C3H mice. Passage of the CA through the gastrointestinal (GI) tract was followed by T1-weighted magnetic resonance imaging (MRI) over a period of 47h, by which time the CA had exited the GI tract. No evidence for leakage of the CA from the GI ...[more]

PMID: 23481651

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Dataset Information

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.

Publications

Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract.

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