Ontology highlight
ABSTRACT:
SUBMITTER: Schott AF
PROVIDER: S-EPMC3602220 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Schott Anne F AF Landis Melissa D MD Dontu Gabriela G Griffith Kent A KA Layman Rachel M RM Krop Ian I Paskett Lacey A LA Wong Helen H Dobrolecki Lacey E LE Lewis Michael T MT Froehlich Amber M AM Paranilam Jaya J Hayes Daniel F DF Wicha Max S MS Chang Jenny C JC
Clinical cancer research : an official journal of the American Association for Cancer Research 20130122 6
<h4>Purpose</h4>Accumulating evidence supports the existence of breast cancer stem cells (BCSC), which are characterized by their capacity to self-renew and divide indefinitely and resistance to conventional therapies. The Notch pathway is important for stem cell renewal and is a potential target for BCSC-directed therapy.<h4>Experimental design</h4>Using human breast tumorgraft studies, we evaluated the impact of gamma secretase inhibitors (GSI) on the BCSC population and the efficacy of combin ...[more]