Ontology highlight
ABSTRACT:
SUBMITTER: Xiao W
PROVIDER: S-EPMC3602244 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
PloS one 20130319 3
Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase catalyzes the transfer of electrons from NADPH to O2, which is the main source of reactive oxygen species (ROS) in nonphagocytic cells. Excess ROS are toxic; therefore, keeping ROS in homeostasis in cells can protect cells from oxidative damage. It is meaningful to further understand the molecular mechanism by which ROS homeostasis is mediated. Human protein HSCARG is a newly identified oxidative sensor and a negative regulator of NF-κB ...[more]