Ontology highlight
ABSTRACT:
SUBMITTER: Lin LJ
PROVIDER: S-EPMC3602290 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Lin Li-Jung LJ Grimme Jill M JM Sun Jie J Lu Shaoying S Gai Lisa L Cropek Donald M DM Wang Yingxiao Y
Biomaterials 20130307 15
Reactive oxygen species (ROS) have been shown to play crucial roles in regulating various cellular functions, e.g. focal adhesion (FA) dynamics and cell migration upon growth factor stimulation. However, it is not clear how ROS are regulated at subcellular FA sites to impact cell migration. We have developed a biosensor capable of monitoring ROS production at FA sites in live cells with high sensitivity and specificity, utilizing fluorescence resonance energy transfer (FRET). The results reveale ...[more]