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Mitochondrial network size scaling in budding yeast.

ABSTRACT: Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all buds attained the same average ratio. Thus, yeast populations achieve a stable scaling relation between mitochondrial content and cell size despite asymmetry in inheritance.

SUBMITTER: Rafelski SM

PROVIDER: S-EPMC3602416 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature

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Mitochondrial network size scaling in budding yeast.

Rafelski Susanne M SM Viana Matheus P MP Zhang Yi Y Chan Yee-Hung M YH Thorn Kurt S KS Thorn Kurt S KS Yam Phoebe P Fung Jennifer C JC Li Hao H Costa Luciano da F Lda F Marshall Wallace F WF

Science (New York, N.Y.) 20121101 6108

Mitochondria must grow with the growing cell to ensure proper cellular physiology and inheritance upon division. We measured the physical size of mitochondrial networks in budding yeast and found that mitochondrial network size increased with increasing cell size and that this scaling relation occurred primarily in the bud. The mitochondria-to-cell size ratio continually decreased in aging mothers over successive generations. However, regardless of the mother's age or mitochondrial content, all ...[more]

PMID: 23139336

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