SLC6 transporters: structure, function, regulation, disease association and therapeutics.
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ABSTRACT:
SUBMITTER: Pramod AB
PROVIDER: S-EPMC3602807 | biostudies-literature | 2013 Apr-Jun
REPOSITORIES: biostudies-literature
Publications
SLC6 transporters: structure, function, regulation, disease association and therapeutics.
Pramod Akula Bala AB Foster James J Carvelli Lucia L Henry L Keith LK
Molecular aspects of medicine 20130401 2-3
The SLC6 family of secondary active transporters are integral membrane solute carrier proteins characterized by the Na(+)-dependent translocation of small amino acid or amino acid-like substrates. SLC6 transporters, which include the serotonin, dopamine, norepinephrine, GABA, taurine, creatine, as well as amino acid transporters, are associated with a number of human diseases and disorders making this family a critical target for therapeutic development. In addition, several members of this fami ...[more]
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