Functional proteomics characterization of residual breast cancer after neoadjuvant systemic chemotherapy.

ABSTRACT:

Background

The purpose of this study was to determine the functional proteomic characteristics of residual breast cancer and hormone receptor (HR)-positive breast cancer after neoadjuvant systemic chemotherapy, and their relationship with patient outcomes.

Methods

Reverse phase protein arrays of 76 proteins were carried out. A boosting approach in conjunction with a Cox proportional hazard model defined relapse predictors. A risk score (RS) was calculated with the sum of the coefficients from the final model. Survival outcomes and associations of the RS with relapse were estimated. An independent test set was used to validate the results.

Results

Test (n = 99) and validation sets (n = 79) were comparable. CoxBoost revealed a three-biomarker (CHK1pS345, Caveolin1, and

SUBMITTER: Gonzalez-Angulo AM 

PROVIDER: S-EPMC3603436 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature