Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans.
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ABSTRACT:
SUBMITTER: Brinkworth JF
PROVIDER: S-EPMC3603697 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Innate immune responses to TLR2 and TLR4 agonists differ between baboons, chimpanzees and humans.
Brinkworth J F JF Pechenkina E A EA Silver J J Goyert S M SM
Journal of medical primatology 20120917 6
<h4>Background</h4>African catarrhine primates differ in bacterial disease susceptibility.<h4>Methods</h4>Human, chimpanzee, and baboon blood were stimulated with TLR-detected bacterial agonists and cytokine/chemokine induction assessed by real-time PCR.<h4>Results</h4>Humans and chimpanzees shared similar cytokine/chemokine responses, while baboon cytokine/chemokine induction differed. Generally, responses were agonist independent.<h4>Conclusions</h4>These primates tend to generate species rath ...[more]
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