Ontology highlight
ABSTRACT:
SUBMITTER: Gloudemans AK
PROVIDER: S-EPMC3603891 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Gloudemans Anouk K AK Plantinga Maud M Guilliams Martin M Willart Monique A MA Ozir-Fazalalikhan Arifa A van der Ham Alwin A Boon Louis L Harris Nicola L NL Hammad Hamida H Hoogsteden Henk C HC Yazdanbakhsh Maria M Hendriks Rudi W RW Lambrecht Bart N BN Smits Hermelijn H HH
PloS one 20130320 3
It is currently unknown how mucosal adjuvants cause induction of secretory immunoglobulin A (IgA), and how T cell-dependent (TD) or -independent (TI) pathways might be involved. Mucosal dendritic cells (DCs) are the primary antigen presenting cells driving TI IgA synthesis, by producing a proliferation-inducing ligand (APRIL), B cell activating factor (BAFF), Retinoic Acid (RA), TGF-β or nitric oxide (NO). We hypothesized that the mucosal adjuvant Cholera Toxin subunit B (CTB) could imprint non- ...[more]