Dataset Information

Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.

ABSTRACT:

Background

Maternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism.

Methods

277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessments included: height and weight corrected for parental measurements, DEXA-derived body composition, fasting lipids, glucose, insulin, and hormonal profiles. Subjects were separated according to maternal age at childbirth: <30, 30-35, and >35 years.

Results

Our cohort consisted of 126 girls and 151 boys, aged 7.4 ± 2.2 years (range 3-10); maternal age at childbirth was 33.3 ± 4.7 years (range 19-44). Children of mothers aged >35 and 30-35 years at childbirth were taller than children of mothers aged <30 years by 0.26 (p?=?0.002) and 0.23 (p?=?0.042) SDS, respectively. There was a reduction in childhood BMISDS with increasing maternal age at childbirth, and children of mothers aged >35 years at childbirth were 0.61 SDS slimmer than those of mothers <30 years (p?=?0.049). Children of mothers aged 30-35 (p?=?0.022) and >35 (p?=?0.036) years at childbirth had abdominal adiposity reduced by 10% and 13%, respectively, compared to those in the <30 group. Children of mothers aged 30-35 years at childbirth displayed a 19% increase in IGF-I concentrations compared to offspring in <30 group (p?=?0.042). Conversely, IGF-II concentrations were lower among the children born to mothers aged 30-35 (6.5%; p?=?0.004) and >35 (8.1%; p?=?0.005) compared to those of mothers aged <30 years. Girls of mothers aged 30-35 years at childbirth also displayed improved HOMA-IR insulin sensitivity (p?=?0.010) compared to girls born to mothers aged <30 years.

Conclusions

Increasing maternal age at childbirth is associated with a more favourable phenotype (taller stature and reduced abdominal fat) in their children, as well as improved insulin sensitivity in girls.

SUBMITTER: Savage T

PROVIDER: S-EPMC3604016 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Publications

Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.

Savage Tim T Derraik José G B JG Miles Harriet L HL Mouat Fran F Hofman Paul L PL Cutfield Wayne S WS

PloS one 20130320 3

<h4>Background</h4>Maternal age at childbirth continues to increase worldwide. We aimed to assess whether increasing maternal age is associated with changes in childhood height, body composition, and metabolism.<h4>Methods</h4>277 healthy pre-pubertal children, born 37-41 weeks gestation were studied. Assessments included: height and weight corrected for parental measurements, DEXA-derived body composition, fasting lipids, glucose, insulin, and hormonal profiles. Subjects were separated accordin ...[more]

PMID: 23527040

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Dataset Information

Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.

Background

Methods

Results

Conclusions

Publications

Increasing maternal age is associated with taller stature and reduced abdominal fat in their children.

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