Ontology highlight
ABSTRACT: Background
Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.Methods
Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order to investigate the genetic contribution of each ancestral group in 236 patients with MS and NMO, diagnosed using the McDonald and Wingerchuck criteria, respectively. All 128 MS patients were recruited at the Faculty of Medicine of Ribeirão Preto (MS-RP), Southeastern Brazil, as well as 108 healthy bone marrow donors considered as healthy controls. A total of 108 NMO patients were recruited from five Neurology centers from different Brazilian regions, including Ribeirão Preto (NMO-RP).Principal findings
European ancestry contribution was higher in MS-RP than in NMO-RP (78.5% vs. 68.7%) patients. In contrast, African ancestry estimates were higher in NMO-RP than in MS-RP (20.5% vs. 12.5%) patients. Moreover, principal component analyses showed that groups of NMO patients from different Brazilian regions were clustered close to the European ancestral population.Conclusions
Our findings demonstrate that European genetic contribution predominates in NMO and MS patients from Brazil.
SUBMITTER: Brum DG
PROVIDER: S-EPMC3604018 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Brum Doralina Guimarães DG Luizon Marcelo Rizzatti MR Santos Antônio Carlos AC Lana-Peixoto Marco Aurélio MA Rocha Cristiane Franklin CF Brito Maria Lucia ML de Oliveira Enedina Maria Lobato EM Bichuetti Denis Bernardi DB Gabbai Alberto Alan AA Diniz Denise Sisterolli DS Kaimen-Maciel Damacio Ramon DR Comini-Frota Elizabeth Regina ER Vieira Wiezel Claudia E CE Muniz Yara Costa Netto YC da Silva Costa Roberta Martins RM Mendes-Junior Celso Teixeira CT Donadi Eduardo Antônio EA Barreira Amilton Antunes AA Simões Aguinaldo Luiz AL
PloS one 20130320 3
<h4>Background</h4>Neuromyelitis optica (NMO) is considered relatively more common in non-Whites, whereas multiple sclerosis (MS) presents a high prevalence rate, particularly in Whites from Western countries populations. However, no study has used ancestry informative markers (AIMs) to estimate the genetic ancestry contribution to NMO patients.<h4>Methods</h4>Twelve AIMs were selected based on the large allele frequency differences among European, African, and Amerindian populations, in order t ...[more]