Ontology highlight
ABSTRACT:
SUBMITTER: Kokel D
PROVIDER: S-EPMC3604056 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Kokel David D Cheung Chung Yan J CY Mills Robert R Coutinho-Budd Jaeda J Huang Liyi L Setola Vincent V Sprague Jared J Jin Shan S Jin Youngnam N YN Huang Xi-Ping XP Bruni Giancarlo G Woolf Clifford J CJ Roth Bryan L BL Hamblin Michael R MR Zylka Mark J MJ Milan David J DJ Peterson Randall T RT
Nature chemical biology 20130210 4
Optogenetics is a powerful research tool because it enables high-resolution optical control of neuronal activity. However, current optogenetic approaches are limited to transgenic systems expressing microbial opsins and other exogenous photoreceptors. Here, we identify optovin, a small molecule that enables repeated photoactivation of motor behaviors in wild-type zebrafish and mice. To our surprise, optovin's behavioral effects are not visually mediated. Rather, photodetection is performed by se ...[more]