Ontology highlight
ABSTRACT:
SUBMITTER: Grunwald M
PROVIDER: S-EPMC3604722 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Grünwald Marlene M Lazzaretti Daniela D Bono Fulvia F
The EMBO journal 20130222 6
Importin13 (Imp13) is a bidirectional karyopherin that can mediate both import and export of cargoes. Imp13 recognizes several import cargoes, which include the exon junction complex components Mago-Y14 and the E2 SUMO-conjugating enzyme Ubc9, and one known export cargo, the translation initiation factor 1A (eIF1A). To understand how Imp13 can perform double duty, we determined the 3.6-Å crystal structure of Imp13 in complex with RanGTP and with eIF1A. eIF1A binds at the inner surface of the Imp ...[more]