Ontology highlight
ABSTRACT:
SUBMITTER: Eggert M
PROVIDER: S-EPMC3605127 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Eggert Marlene M Pfob Martina M Steinlein Ortrud K OK
BMC research notes 20130315
<h4>Background</h4>The melanocortin-3-receptor (MC3R) is a member of the G-protein coupled receptor family that mediate cellular response through the cyclic adenosine monophosphate signalling pathway. In the promoter region of MC3R the polymorphism rs6127698 has previously been shown to be strongly associated with tuberculosis susceptibility. It is predicted to generate an alternative transcription factor binding site.<h4>Findings</h4>We investigated the functional impact of rs6127698 by lucifer ...[more]