TNFAIP3 gene polymorphisms in a Chinese Han population with Vogt-Koyanagi-Harada syndrome.

ABSTRACT:

Background

This study was performed to evaluate the potential association of TNFAIP3 polymorphisms with Vogt-Koyanagi-Harada (VKH) disease in a Chinese Han population.

Methodology/principal findings

Five single-nucleotide polymorphisms (SNPs), rs10499194, rs610604, rs7753873, rs5029928 and rs9494885 of TNFAIP3 were genotyped in 834 VKH disease patients and 1415 healthy controls using a PCR-restriction fragment length polymorphism assay. An increased frequency of the C allele and CT genotype for rs9494885 were found in VKH patients in the Guangzhou and Chongqing cohorts (pc?=?0.015, OR?=?1.6, pc?=?0.036, OR?=?1.7; pc?=?2.36×10-4, OR?=?1.5, pc?=?0.012, OR?=?1.5, respectively). Meanwhile, a decreased frequency of the TT genotype for rs9494885 was observed in VKH patients in the Guangzhou and Chongqing cohorts (pc?=?0.026, OR?=?0.6, pc?=?0.0074, OR?=?0.7, respectively). The combined analysis showed that a significantly increased prevalence of the rs9494885 TC genotype and C allele were found in VKH disease patients compared with controls (pc?=?2.26×10-5, OR?=?1.7; pc?=?1.09× 10-5, OR?=?1.6, respectively). The frequency of the TT genotype of rs9494885 was markedly lower in VKH disease patients as compared with that in controls (pc?=?1.12×10-5, OR?=?0.6; pc?=?1.09×10(-5), OR?=?0.6, respectively). No association was found between rs10499194, rs610604, rs7753873 and rs5029928 polymorphisms and VKH disease. To our knowledge this is the first report describing the association of a TNFAIP3 gene polymorphism with VKH disease in a Chinese Han population.

Conclusions/significance

The results suggest that the rs9494885 TC genotype and C allele may be predisposing factors to VKH disease, whereas the rs9494885 TT genotype and T allele may provide protection against this disease.

SUBMITTER: Li H 

PROVIDER: S-EPMC3605404 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature