Ontology highlight
ABSTRACT:
SUBMITTER: Park M
PROVIDER: S-EPMC3605428 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Park Minyoung M Wetzler Modi M Jardetzky Theodore S TS Barron Annelise E AE
PloS one 20130321 3
Incorporation of unnatural amino acids and peptidomimetic residues into therapeutic peptides is highly efficacious and commonly employed, but generally requires laborious trial-and-error approaches. Previously, we demonstrated that C20 peptide has the potential to be a potential antiviral agent. Herein we report our attempt to improve the biological properties of this peptide by introducing peptidomimetics. Through combined alanine, proline, and sarcosine scans coupled with a competitive fluores ...[more]