Ontology highlight
ABSTRACT:
SUBMITTER: Heatley SL
PROVIDER: S-EPMC3605686 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Heatley Susan L SL Pietra Gabriella G Lin Jie J Widjaja Jacqueline M L JML Harpur Christopher M CM Lester Sue S Rossjohn Jamie J Szer Jeff J Schwarer Anthony A Bradstock Kenneth K Bardy Peter G PG Mingari Maria Cristina MC Moretta Lorenzo L Sullivan Lucy C LC Brooks Andrew G AG
The Journal of biological chemistry 20130118 12
Natural killer (NK) cell recognition of the nonclassical human leukocyte antigen (HLA) molecule HLA-E is dependent on the presentation of a nonamer peptide derived from the leader sequence of other HLA molecules to CD94-NKG2 receptors. However, human cytomegalovirus can manipulate this central innate interaction through the provision of a "mimic" of the HLA-encoded peptide derived from the immunomodulatory glycoprotein UL40. Here, we analyzed UL40 sequences isolated from 32 hematopoietic stem ce ...[more]