Ontology highlight
ABSTRACT:
SUBMITTER: Chakkalakal JV
PROVIDER: S-EPMC3605795 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Chakkalakal Joe V JV Jones Kieran M KM Basson M Albert MA Brack Andrew S AS
Nature 20120926 7420
The niche is a conserved regulator of stem cell quiescence and function. During ageing, stem cell function declines. To what extent and by what means age-related changes within the niche contribute to this phenomenon are unknown. Here we demonstrate that the aged muscle stem cell niche, the muscle fibre, expresses Fgf2 under homeostatic conditions, driving a subset of satellite cells to break quiescence and lose their self-renewing capacity. We show in mice that relatively dormant aged satellite ...[more]