Ontology highlight
ABSTRACT:
SUBMITTER: Chattopadhyay A
PROVIDER: S-EPMC3606004 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Chattopadhyay Arnab A Navab Mohamad M Hough Greg G Gao Feng F Meriwether David D Grijalva Victor V Springstead James R JR Palgnachari Mayakonda N MN Namiri-Kalantari Ryan R Su Feng F Van Lenten Brian J BJ Wagner Alan C AC Anantharamaiah G M GM Farias-Eisner Robin R Reddy Srinivasa T ST Fogelman Alan M AM
Journal of lipid research 20130202 4
Transgenic tomato plants were constructed with an empty vector (EV) or a vector expressing an apoA-I mimetic peptide, 6F. EV or 6F tomatoes were harvested, lyophilized, ground into powder, added to Western diet (WD) at 2.2% by weight, and fed to LDL receptor-null (LDLR(-/-)) mice at 45 mg/kg/day 6F. After 13 weeks, the percent of the aorta with lesions was 4.1 ± 4%, 3.3 ± 2.4%, and 1.9 ± 1.4% for WD, WD + EV, and WD + 6F, respectively (WD + 6F vs. WD, P = 0.0134; WD + 6F vs. WD + EV, P = 0.0386; ...[more]