Ontology highlight
ABSTRACT:
SUBMITTER: Vandenberg CJ
PROVIDER: S-EPMC3606065 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Blood 20130122 12
BH3-only proteins trigger the stress apoptosis pathway and chemical mimetics have great potential for cancer therapy. BH3-only proteins inhibit antiapoptotic members of the Bcl-2 family. Promising BH3 mimetic ABT-737 and the related orally available compound ABT-263 (navitoclax) bind avidly to antiapoptotic Bcl-2, Bcl-xL, and Bcl-w. However, their interaction with Bcl-xL provokes thrombocytopenia, which has proven to be the dose-limiting toxicity. We have tested the efficacy of ABT-199, a new Bc ...[more]