Ontology highlight
ABSTRACT:
SUBMITTER: Schwoebel F
PROVIDER: S-EPMC3606066 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Schwoebel Frank F van Eijk Lucas T LT Zboralski Dirk D Sell Simone S Buchner Klaus K Maasch Christian C Purschke Werner G WG Humphrey Martin M Zöllner Stefan S Eulberg Dirk D Morich Frank F Pickkers Peter P Klussmann Sven S
Blood 20130124 12
Anemia of chronic inflammation is the most prevalent form of anemia in hospitalized patients. A hallmark of this disease is the intracellular sequestration of iron. This is a consequence of hepcidin-induced internalization and subsequent degradation of ferroportin, the hepcidin receptor and only known iron-export protein. This study describes the characterization of novel anti-hepcidin compound NOX-H94, a structured L-oligoribonucleotide that binds human hepcidin with high affinity (Kd = 0.65 ± ...[more]