Integrated proteomics and metabolomics of Arabidopsis acclimation to gene-dosage dependent perturbation of isopropylmalate dehydrogenases.
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ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC3606340 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Publications
Integrated proteomics and metabolomics of Arabidopsis acclimation to gene-dosage dependent perturbation of isopropylmalate dehydrogenases.
He Yan Y Dai Shaojun S Dufresne Craig P CP Zhu Ning N Pang Qiuying Q Chen Sixue S
PloS one 20130322 3
Maintaining metabolic homeostasis is critical for plant growth and development. Here we report proteome and metabolome changes when the metabolic homeostasis is perturbed due to gene-dosage dependent mutation of Arabidopsis isopropylmalate dehydrogenases (IPMDHs). By integrating complementary quantitative proteomics and metabolomics approaches, we discovered that gradual ablation of the oxidative decarboxylation step in leucine biosynthesis caused imbalance of amino acid homeostasis, redox chang ...[more]
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