Ontology highlight
ABSTRACT:
SUBMITTER: Varshney M
PROVIDER: S-EPMC3606560 | biostudies-literature | 2004 Apr
REPOSITORIES: biostudies-literature
Varshney Manoj M Morey Timothy E TE Shah Dinesh O DO Flint Jason A JA Moudgil Brij M BM Seubert Christoph N CN Dennis Donn M DM
Journal of the American Chemical Society 20040401 16
We hypothesized that custom-designed microemulsions would effectively scavenge compounds from bulk media. Pluronic-based oil-in-water microemulsions were synthesized that efficiently reduced the free concentration of the local anesthetic bupivacaine in 0.9% NaCl. Both the molecular nature and concentration of the constituents in the microemulsions significantly affected extraction efficiencies. Pluronic F127-based microemulsions extracted bupivacaine more efficiently than microemulsions synthesi ...[more]