Ontology highlight
ABSTRACT:
SUBMITTER: Goicoechea de Jorge E
PROVIDER: S-EPMC3606973 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Goicoechea de Jorge Elena E Caesar Joseph J E JJ Malik Talat H TH Patel Mitali M Colledge Matthew M Johnson Steven S Hakobyan Svetlana S Morgan B Paul BP Harris Claire L CL Pickering Matthew C MC Lea Susan M SM
Proceedings of the National Academy of Sciences of the United States of America 20130304 12
The complement system is a key component regulation influences susceptibility to age-related macular degeneration, meningitis, and kidney disease. Variation includes genomic rearrangements within the complement factor H-related (CFHR) locus. Elucidating the mechanism underlying these associations has been hindered by the lack of understanding of the biological role of CFHR proteins. Here we present unique structural data demonstrating that three of the CFHR proteins contain a shared dimerization ...[more]