Ontology highlight
ABSTRACT:
SUBMITTER: Volmer R
PROVIDER: S-EPMC3606975 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Volmer Romain R van der Ploeg Kattria K Ron David D
Proceedings of the National Academy of Sciences of the United States of America 20130304 12
Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors, signaling an unfolded protein response (UPR) that maintains compartment-specific protein folding homeostasis. Surprisingly, perturbation of cellular lipid composition also activates the UPR, with important consequences in obesity and diabetes. However, it is unclear if direct sensing of the lipid perturbation contributes to UPR activation. We ...[more]