Ontology highlight
ABSTRACT:
SUBMITTER: Matsunari H
PROVIDER: S-EPMC3607052 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Matsunari Hitomi H Nagashima Hiroshi H Watanabe Masahito M Umeyama Kazuhiro K Nakano Kazuaki K Nagaya Masaki M Kobayashi Toshihiro T Yamaguchi Tomoyuki T Sumazaki Ryo R Herzenberg Leonard A LA Nakauchi Hiromitsu H
Proceedings of the National Academy of Sciences of the United States of America 20130219 12
In the field of regenerative medicine, one of the ultimate goals is to generate functioning organs from pluripotent cells, such as ES cells or induced pluripotent stem cells (PSCs). We have recently generated functional pancreas and kidney from PSCs in pancreatogenesis- or nephrogenesis-disabled mice, providing proof of principle for organogenesis from PSCs in an embryo unable to form a specific organ. Key when applying the principles of in vivo generation to human organs is compensation for an ...[more]