Ontology highlight
ABSTRACT:
SUBMITTER: Innos J
PROVIDER: S-EPMC3607788 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Innos Jürgen J Koido Kati K Philips Mari-Anne MA Vasar Eero E
Frontiers in pharmacology 20130326
The studies performed in laboratory animals and psychiatric patients suggest a possible role of limbic system-associated membrane protein (LAMP) in the mechanisms of psychiatric disorders. Stressful manipulations and genetic invalidation have revealed a role of the Lsamp gene in the regulation of anxiety in rodents. Besides that, Lsamp-deficient mice display reduced aggressiveness and impaired adaptation in novel and stressful environments. The behavioral effects of amphetamine were blunted in g ...[more]