Ontology highlight
ABSTRACT:
SUBMITTER: Tameris M
PROVIDER: S-EPMC3608032 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Tameris Michele M McShane Helen H McClain J Bruce JB Landry Bernard B Lockhart Stephen S Luabeya Angelique K K AK Geldenhuys Hennie H Shea Jacqui J Hussey Gregory G van der Merwe Linda L de Kock Marwou M Scriba Thomas T Walker Robert R Hanekom Willem W Hatherill Mark M Mahomed Hassan H
Tuberculosis (Edinburgh, Scotland) 20130212 2
<h4>Background</h4>New tuberculosis (TB) vaccines are being developed to combat the global epidemic. A phase IIb trial of a candidate vaccine, MVA85A, was conducted in a high burden setting in South Africa to evaluate proof-of-concept efficacy for prevention of TB in infants.<h4>Objective</h4>To describe the study design and implementation lessons from an infant TB vaccine efficacy trial.<h4>Methods</h4>This was a randomised, controlled, double-blind clinical trial comparing the safety and effic ...[more]