Designs combining instrumental variables with case-control: estimating principal strata causal effects.
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ABSTRACT:
SUBMITTER: Shinohara RT
PROVIDER: S-EPMC3608098 | biostudies-literature | 2012 Jan
REPOSITORIES: biostudies-literature
Publications
Designs combining instrumental variables with case-control: estimating principal strata causal effects.
Shinohara Russell T RT Frangakis Constantine E CE Platz Elizabeth E Tsilidis Konstantinos K
The international journal of biostatistics 20120106 1
The instrumental variables framework is commonly used for the estimation of causal effects from cohort samples. However, the combination of instrumental variables with more efficient designs such as case-control sampling requires new methodological consideration. For example, as the use of Mendelian randomization studies is increasing and the cost of genotyping and gene expression data can be high, the analysis of data gathered from more cost-effective sampling designs is of prime interest. We s ...[more]
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