Ontology highlight
ABSTRACT:
SUBMITTER: Smith BA
PROVIDER: S-EPMC3608398 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Molecular pharmaceutics 20110301 2
Cell death is a fundamental biological process that is present in numerous disease pathologies. Fluorescent probes that detect cell death have been developed for a myriad of research applications ranging from microscopy to in vivo imaging. Here we describe a synthetic near-infrared (NIR) conjugate of zinc(II)-dipicolylamine (Zn²+-DPA) for in vivo imaging of cell death. Chemically induced in vivo models of myopathy were established using an ionphore, ethanol, or ketamine as cytotoxins. The Zn²+-D ...[more]