Unknown

Dataset Information

0

Biomarkers of Alzheimer's disease among Mexican Americans.


ABSTRACT: Mexican Americans are the fastest aging segment of the U.S. population, yet little scientific literature exists regarding the Alzheimer's disease (AD) among this segment of the population. The extant literature suggests that biomarkers of AD will vary according to race/ethnicity though no prior work has explicitly studied this possibility. The aim of this study was to create a serum-based biomarker profile of AD among Mexican American.Data were analyzed from 363 Mexican American participants (49 AD and 314 normal controls) enrolled in the Texas Alzheimer's Research & Care Consortium (TARCC). Non-fasting serum samples were analyzed using a luminex-based multi-plex platform. A biomarker profile was generated using random forest analyses.The biomarker profile of AD among Mexican Americans was different from prior work from non-Hispanic populations with regards to the variable importance plots. In fact, many of the top markers were related to metabolic factors (e.g., FABP, GLP-1, CD40, pancreatic polypeptide, insulin-like-growth factor, and insulin). The biomarker profile was a significant classifier of AD status yielding an area under the receiver operating characteristic curve, sensitivity, and specificity of 0.77, 0.92, and 0.64, respectively. Combining biomarkers with clinical variables yielded a better balance of sensitivity and specificity.The biomarker profile for AD among Mexican American cases is significantly different from that previously identified among non-Hispanic cases from many large-scale studies. This is the first study to explicitly examine and provide support for blood-based biomarkers of AD among Mexican Americans. Areas for future research are highlighted.

SUBMITTER: O'Bryant SE 

PROVIDER: S-EPMC3608404 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

altmetric image

Publications

Biomarkers of Alzheimer's disease among Mexican Americans.

O'Bryant Sid E SE   Xiao Guanghua G   Edwards Melissa M   Devous Michael M   Gupta Veer Bala VB   Martins Ralph R   Zhang Fan F   Barber Robert R  

Journal of Alzheimer's disease : JAD 20130101 4


<h4>Background</h4>Mexican Americans are the fastest aging segment of the U.S. population, yet little scientific literature exists regarding the Alzheimer's disease (AD) among this segment of the population. The extant literature suggests that biomarkers of AD will vary according to race/ethnicity though no prior work has explicitly studied this possibility. The aim of this study was to create a serum-based biomarker profile of AD among Mexican American.<h4>Methods</h4>Data were analyzed from 36  ...[more]

Similar Datasets

| S-EPMC7902984 | biostudies-literature
| S-EPMC10055654 | biostudies-literature
| S-EPMC7176060 | biostudies-literature
| S-EPMC5562658 | biostudies-other
| S-EPMC9026506 | biostudies-literature
| S-EPMC7953425 | biostudies-literature
| S-EPMC3726785 | biostudies-literature
| S-EPMC8773964 | biostudies-literature
| S-EPMC8749476 | biostudies-literature
| S-EPMC10081722 | biostudies-literature