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Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.
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ABSTRACT:
SUBMITTER: Chen H
PROVIDER: S-EPMC3608738 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Publications
Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.
Antiviral research 20121222 3
The flavivirus methyltransferase (MTase) sequentially methylates the N-7 and 2'-O positions of the viral RNA cap (GpppA-RNA→m(7)GpppA-RNA→m(7)GpppAm-RNA), using S-adenosyl-l-methionine (SAM) as a methyl donor. We report here the synthesis and biological evaluation of a series of novel nucleoside analogs. Two of these compounds can effectively and competitively inhibit the WNV MTase with IC50 values in micromolar range and, more importantly, do not inhibit human MTase. The compounds can also supp ...[more]
