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Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.

ABSTRACT: The flavivirus methyltransferase (MTase) sequentially methylates the N-7 and 2'-O positions of the viral RNA cap (GpppA-RNA?m(7)GpppA-RNA?m(7)GpppAm-RNA), using S-adenosyl-l-methionine (SAM) as a methyl donor. We report here the synthesis and biological evaluation of a series of novel nucleoside analogs. Two of these compounds can effectively and competitively inhibit the WNV MTase with IC50 values in micromolar range and, more importantly, do not inhibit human MTase. The compounds can also suppress the WNV replication in cell culture.

SUBMITTER: Chen H

PROVIDER: S-EPMC3608738 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature

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Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.

Chen Hui H Liu Lihui L Jones Susan A SA Banavali Nilesh N Kass Jorden J Li Zhong Z Zhang Jing J Kramer Laura D LD Ghosh Arun K AK Li Hongmin H

Antiviral research 20121222 3

The flavivirus methyltransferase (MTase) sequentially methylates the N-7 and 2'-O positions of the viral RNA cap (GpppA-RNA→m(7)GpppA-RNA→m(7)GpppAm-RNA), using S-adenosyl-l-methionine (SAM) as a methyl donor. We report here the synthesis and biological evaluation of a series of novel nucleoside analogs. Two of these compounds can effectively and competitively inhibit the WNV MTase with IC50 values in micromolar range and, more importantly, do not inhibit human MTase. The compounds can also supp ...[more]

PMID: 23267828

Dataset Information

Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.

Publications

Selective inhibition of the West Nile virus methyltransferase by nucleoside analogs.

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