Dataset Information
Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence.
Ontology highlight
ABSTRACT: Purpose
To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents.Methods
Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling.Results
Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relapse. Adolescents receiving bupropion and females provided significantly fewer methamphetamine-free urine tests compared to participants receiving placebo (p = .043) and males (p = .005) respectively.Conclusions
Results do not support the feasibility of additional trials of bupropion for adolescent methamphetamine abuse/dependence. Future studies should investigate the influence of gender on adolescent methamphetamine abuse and treatment outcomes.
SUBMITTER: Heinzerling KG
PROVIDER: S-EPMC3608805 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Pilot randomized trial of bupropion for adolescent methamphetamine abuse/dependence.
The Journal of adolescent health : official publication of the Society for Adolescent Medicine 20130117 4
<h4>Purpose</h4>To perform a pilot clinical trial of bupropion for methamphetamine abuse/dependence among adolescents.<h4>Methods</h4>Nineteen adolescents with methamphetamine abuse (n = 2) or dependence (n = 17) were randomly assigned to bupropion SR 150 mg twice daily or placebo for 8 weeks with outpatient substance abuse counseling.<h4>Results</h4>Bupropion was well-tolerated except for one female in the bupropion group who was hospitalized for suicidal ideation during a methamphetamine relap ...[more]
