A randomized comparison of a commercially available portion-controlled weight-loss intervention with a diabetes self-management education program.
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ABSTRACT: This study examined the efficacy of a commercially available, portion-controlled diet (PCD) on body weight and HbA1c over 6 months in obese patients with type 2 diabetes.One-hundred participants with a mean±s.d. age of 55.6±10.6 year, body weight of 102.9±18.4?kg and HbA1c of 7.7±1.3% were randomly assigned to a 9-session group lifestyle intervention that included a PCD or to a 9-session group program of diabetes self-management education (DSME). Participants in the two groups were prescribed the same goals for energy intake (1250-1550?kcal per day) and physical activity (200?min per week).While both groups produced significant improvements in weight and HbA1c after 6 months of treatment, PCD participants lost 7.3?kg [95% confidence interval (CI): -5.8 to -8.8?kg], compared with 2.2?kg (95% CI: -0.7 to -3.7?kg) in the DSME group (P<0.0001). Significantly more PCD than DSME participants lost ?5% of initial weight (54.0% vs 14.0%, P<0.0001) and ?10% (26.0% vs 6.0%, P<0.0001). HbA1c declined by 0.7% (95% CI: -0.4 to -1.0%) in the PCD group, compared with 0.4% (95% CI: -0.1 to -0.7%) in DSME (P<0.026). Across both groups, larger weight losses were associated with greater reductions in HbA1c (r=0.52, P<0.0001).These findings demonstrate that a commercially available portion-controlled meal plan can induce clinically meaningful improvements in weight and glycemic control in obese individuals with type 2 diabetes. These data have implications for the management of obesity in primary care, as now provided by the Centers for Medicare and Medicaid Services.
SUBMITTER: Foster GD
PROVIDER: S-EPMC3608893 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
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