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Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.

ABSTRACT: A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared to in situ breast cancer. MMP-1 2G insertion polymorphism in the invasive group also correlated significantly with the expression of MMP-1 and breast cancer prognostic markers HER2 and P53.

SUBMITTER: Zhou J

PROVIDER: S-EPMC3609030 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature

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Analysis of matrix metalloproteinase-1 gene polymorphisms and expression in benign and malignant breast tumors.

Zhou Jing J Brinckerhoff Constance C Lubert Susan S Yang Kui K Saini Jasmine J Hooke Jeffrey J Mural Richard R Shriver Craig C Somiari Stella S

Cancer investigation 20111101 9

A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared ...[more]

PMID: 22011282

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| S-EPMC7412950 | biostudies-literature

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Project description: Not available

| S-EPMC2701308 | biostudies-literature

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