Ontology highlight
ABSTRACT:
SUBMITTER: Zhou J
PROVIDER: S-EPMC3609030 | biostudies-literature | 2011 Nov
REPOSITORIES: biostudies-literature
Cancer investigation 20111101 9
A guanine insertion polymorphism in matrix metalloproteinase-1 promoter (MMP-1 2G) is linked to early onset and aggressiveness in cancer. We determined the role of MMP-1 2G on MMP-1 expression and breast cancer severity in patients with breast diseases. We observed no significant difference in genotype distribution among different disease groups. However, MMP-1 expression was significantly higher in atypical ductal hyperplasia than in benign breast disease and in invasive breast cancer compared ...[more]