Neuronal Ca(2+) dyshomeostasis in Huntington disease.
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ABSTRACT:
SUBMITTER: Giacomello M
PROVIDER: S-EPMC3609054 | biostudies-literature | 2013 Jan-Feb
REPOSITORIES: biostudies-literature
Publications
Neuronal Ca(2+) dyshomeostasis in Huntington disease.
Giacomello Marta M Oliveros Juan C JC Naranjo Jose R JR Carafoli Ernesto E
Prion 20130101 1
The expansion of the N-terminal poly-glutamine tract of the huntingtin (Htt) protein is responsible for Huntington disease (HD). A large number of studies have explored the neuronal phenotype of HD, but the molecular aethiology of the disease is still very poorly understood. This has hampered the development of an appropriate therapeutical strategy to at least alleviate its symptoms. In this short review, we have focused our attention on the alteration of a specific cellular mechanism common to ...[more]
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