Prion formation by a yeast GLFG nucleoporin.
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ABSTRACT:
SUBMITTER: Halfmann R
PROVIDER: S-EPMC3609069 | biostudies-literature | 2012 Sep-Oct
REPOSITORIES: biostudies-literature
Publications
Prion formation by a yeast GLFG nucleoporin.
Halfmann Randal R Wright Jessica R JR Alberti Simon S Lindquist Susan S Rexach Michael M
Prion 20120507 4
The self-assembly of proteins into higher order structures is both central to normal biology and a dominant force in disease. Certain glutamine/asparagine (Q/N)-rich proteins in the budding yeast Saccharomyces cerevisiae assemble into self-replicating amyloid-like protein polymers, or prions, that act as genetic elements in an entirely protein-based system of inheritance. The nuclear pore complex (NPC) contains multiple Q/N-rich proteins whose self-assembly has also been proposed to underlie str ...[more]
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