Ontology highlight
ABSTRACT:
SUBMITTER: Lu Y
PROVIDER: S-EPMC3609554 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Lu Yan Y Xiong Xuelian X Wang Xiaolin X Zhang Zhijian Z Li Jin J Shi Guojun G Yang Jian J Zhang Huijie H Ning Guang G Li Xiaoying X
Diabetes 20121127 4
Gluconeogenesis is critical in maintaining blood glucose levels in a normal range during fasting. In this study, we investigated the role of Yin Yang 1 (YY1), a key transcription factor involved in cell proliferation and differentiation, in the regulation of hepatic gluconeogenesis. Our data showed that hepatic YY1 expression levels were induced in mice during fasting conditions and in a state of insulin resistance. Overexpression of YY1 in livers augmented gluconeogenesis, raising fasting blood ...[more]