Ontology highlight
ABSTRACT:
SUBMITTER: Zhang LN
PROVIDER: S-EPMC3609556 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Zhang Li-Na LN Zhou Hua-Yong HY Fu Yan-Yun YY Li Yuan-Yuan YY Wu Fang F Gu Min M Wu Ling-Yan LY Xia Chun-Mei CM Dong Tian-Cheng TC Li Jing-Ya JY Shen Jing-Kang JK Li Jia J
Diabetes 20121218 4
Peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) has been shown to influence energy metabolism. Hence, we explored a strategy to target PGC-1α expression to treat metabolic syndromes. We developed a high-throughput screening assay that uses the human PGC-1α promoter to drive expression of luciferase. The effects of lead compound stimulation on PGC-1α expression in muscle cells and hepatocytes were investigated in vitro and in vivo. A novel small molecule, ZLN005, led to chang ...[more]