Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites.
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ABSTRACT:
SUBMITTER: Snead AN
PROVIDER: S-EPMC3609712 | biostudies-literature | 2008 Nov
REPOSITORIES: biostudies-literature
Publications
Trace amine-associated receptor 1 (TAAR1) is activated by amiodarone metabolites.
Snead Aaron N AN Miyakawa Motonori M Tan Edwin S ES Scanlan Thomas S TS
Bioorganic & medicinal chemistry letters 20080809 22
Amiodarone (Cordarone, Wyeth-Ayerst Pharmaceuticals) is a clinically available drug used to treat a wide variety of cardiac arrhythmias. We report here the synthesis and characterization of a panel of potential amiodarone metabolites that have significant structural similarity to thyroid hormone and its metabolites the iodothyronamines. Several of these amiodarone derivatives act as specific agonists of the G protein-coupled receptor (GPCR) trace amine-associated receptor 1 (TAAR(1)). This resul ...[more]
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