Ontology highlight
ABSTRACT:
SUBMITTER: Martin S
PROVIDER: S-EPMC3609765 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Martin Sally S Harper Callista B CB May Linda M LM Coulson Elizabeth J EJ Meunier Frederic A FA Osborne Shona L SL
PloS one 20130327 3
The lipid phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P 2), synthesised by PIKfyve, regulates a number of intracellular membrane trafficking pathways. Genetic alteration of the PIKfyve complex, leading to even a mild reduction in PtdIns(3,5)P 2, results in marked neurodegeneration via an uncharacterised mechanism. In the present study we have shown that selectively inhibiting PIKfyve activity, using YM-201636, significantly reduces the survival of primary mouse hippocampal neurons in cultu ...[more]