Ontology highlight
ABSTRACT:
SUBMITTER: Orenstein SJ
PROVIDER: S-EPMC3609872 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Nature neuroscience 20130303 4
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone-mediated autophagy (CMA), whereas the most common pathogenic mutant form of LRRK2, G2019S, was poorly degraded by this pathway. In contrast to the behavior of typical CMA substrates, lysosomal binding of both wild-type and several pathogenic mutant LRRK2 proteins was enhanced in the presence of other CMA substrates, which interfered ...[more]